Table 2.
Hematological analysis after different treatments
| Parameters | Control | TiO2 NPs (mg/kg)
|
Fe3O4-TiO2 NPs (mg/kg)
|
||||
|---|---|---|---|---|---|---|---|
| 5 | 15 | 30 | 5 | 15 | 30 | ||
| WBCs (×109/L) | 10.72±2.56 | 7.38±1.35a | 8.76±1.72 | 8.24±1.76 | 8.78±1.29 | 8.79±2.21 | 11.66±2.28 |
| Neutrophils (%) | 14.86±7.15 | 17.07±7.20 | 19.42±9.34 | 20.10±7.47 | 23.23±4.82 | 16.96±5.83 | 22.36±6.58 |
| Lymphocytes (%) | 83.56±2.83 | 79.53±8.50 | 84.40±3.78 | 81.36±6.27 | 76.45±5.19 | 80.17±3.05 | 77.84±5.82 |
| Monocytes (%) | 2.22±1.60 | 1.97±0.97 | 3.38±1.58 | 2.88±0.64 | 1.68±2.20 | 3.31±1.73 | 2.90±2.68 |
| Eosinophils (%) | 0.88±0.26 | 0.53±0.26 | 0.94±0.29 | 2.25±3.87 | 0.87±0.51 | 0.79±0.32 | 0.92±0.37 |
| Basophils (%) | 0.10±0.07 | 0.12±0.15 | 0.04±0.05 | 0.08±0.04 | 0.05±0.05 | 0.09±0.04 | 0.06±0.05 |
| Neutrophils (%) | 1.53±0.90 | 1.26±0.56 | 1.68±0.74 | 1.59±0.47 | 2.08±0.61 | 1.43±0.46 | 2.66±1.01 |
| Lymphocytes (%) | 8.36±0.79 | 5.79±1.42a | 7.30±1.41 | 6.61±1.51 | 6.49±0.74 | 7.02±1.94 | 8.84±1.52 |
| Monocytes (%) | 0.22±0.16 | 0.16±0.11 | 0.29±0.13 | 0.24±0.10 | 0.14±0.19 | 0.32±0.20 | 0.35±0.37 |
| Eosinophils (%) | 0.09±0.03 | 0.03±0.02 | 0.08±0.03 | 0.21±0.36 | 0.08±0.05 | 0.07±0.04 | 0.10±0.03 |
| RBCs (×1012/L) | 7.51±0.14 | 7.18±0.57 | 7.46±0.44 | 7.45±0.24 | 7.26±0.90 | 7.11±0.67 | 7.01±0.68 |
| Hb (g/L) | 141.80±5.12 | 138.83±10.07 | 138.04±5.60 | 140.80±7.40 | 138.17±14.12 | 132.57±11.00 | 133.20±15.47 |
| Hematocrit | 0.44±0.01 | 0.43±0.03 | 0.43±0.02 | 0.44±0.02 | 0.43±0.03 | 0.42±0.03 | 0.42±0.04 |
| MCV (fL) | 58.64±1.68 | 59.70±1.73 | 57.92±2.00 | 58.50±1.20 | 59.78±3.76 | 58.39±2.62 | 60.22±1.68 |
| MCH (pg) | 18.86±0.71 | 19.38±0.56 | 18.56±0.73 | 18.92±0.63 | 19.12±0.62 | 18.66±0.60 | 18.94±0.59 |
| MCHC (g/L) | 321.60±4.88 | 324.83±3.97 | 320.80±4.44 | 323.00±4.30 | 319.83±9.95 | 319.57±5.71 | 314.80±11.43 |
| RDW-CV (%) | 13.26±0.63 | 13.37±0.45 | 13.34±0.44 | 13.16±0.34 | 14.32±3.38 | 14.00±1.04 | 14.98±2.93 |
| Platelet count (×109/L) | 751.20±239.82 | 630.67±159.65 | 736.00±104.9 | 545.60±261.68 | 586.00±189.9 | 727.57±84.60 | 756.60±74.29 |
| PDW-CV (%) | 14.94±0.05 | 14.90±0.09 | 14.88±0.08 | 14.96±0.13 | 14.95±0.08 | 14.81±0.11 | 14.88±0.18 |
| MPV (fL) | 6.88±0.08 | 6.83±0.08 | 6.86±0.18 | 6.86±0.25 | 6.78±0.12 | 6.73±0.11 | 6.76±0.25 |
| Plateletcrit (%) | 0.57±0.18 | 0.48±0.13 | 0.56±0.17 | 0.42±0.20 | 0.44±0.14 | 0.54±0.06 | 0.57±0.06 |
Notes: Results given as means ± SD (aP<0.05 compared with control).
Abbreviations: Hb, hemoglobin; MCH, mean corpuscular Hb; MCHC, MCH concentration; MCV, mean corpuscular volume; MPV, mean platelet volume; NPs, nanoparticles; PDW-CV, platelet-distribution width coefficient of variation; RBCs, red BCs; RDW-CV, RBC-distribution-width coefficient of variation; WBCs, white blood cells.