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. Author manuscript; available in PMC: 2018 Nov 5.
Published in final edited form as: Comput Chem Eng. 2018 Feb 21;116:322–332. doi: 10.1016/j.compchemeng.2018.02.013

Table 2.

Key nonpolar interactions between AS10 subunit residues and corresponding residues of the amyloidogenic proteins contributing to multi-target binding of AS10.

AS10 residue (subunit 1) IAPP residue Aβ residue α-syn residue
Ile16 Leu16 Phe20 Val40
Tyr18 Leu16 Phe20 Val40
Leu27 Phe23 Ile32 His50
Phe30 Ala25 Leu34 Val52
Phe31 Ala25 Leu34 Val52
Phe31 Phe15 Phe19 Tyr39
Val34 Ala13 Leu17 Val37
Ser41 Ala13 Leu17 Val37
Leu45 Ala13 Leu17 Val37
Leu45 Ala25 Leu34 Val52
Leu45 Leu27 Val36 Thr54
AS10 residue (subunit 2)
Leu27 Phe15 Phe19 Tyr39
Phe31 Phe23 Ile32 His50
Val34 Asn21 Ala30 Val48
Leu45 Val17 Ala21 Gly41