Table 1.
Demyelination of Optic Nerves of Female BALB/c Mice at Various Times after Infection with HSV-IL-2
| Pattern of Optic Nerve Demyelination | |||
|---|---|---|---|
| Days PI | Focal | Diffuse | Total |
| 3 | 0/5 (0) | 0/5 (0) | 0/5 (0) |
| 7 | 0/5 (0) | 0/5 (0) | 0/5 (0) |
| 10 | 2/5 (40) | 3/5 (60) | 3/5 (60) |
| 30 | 2/5 (40) | 3/5 (60) | 5/5 (100) |
| 60 | 1/5 (20) | 3/5 (60) | 4/5 (80) |
Female BALB/c mice were infected with 2 × 105 PFU/eye of HSV-IL-2, and the optic nerves were dissected at the indicated time points and fixed, sectioned, and stained with LFB. Ten sections per mouse were examined for evidence of demyelination. Data are presented as the number of mice showing optic nerve demyelination/total mice tested (%). Control animals were female BALB/c mice similarly infected with HSV-IL-4, HSV-IFN-γ, KOS, McKrae, or dLAT2903 parental virus (five mice per group). No areas of demyelination or plaque were detected in the optic nerves of mice infected with control viruses.