Table 2.
Optic Nerve Demyelination in Male and Female BALB/c Mice at 14 Days after Infection With HSV-IL-2
| Pattern of Optic Nerve Demyelination | |||
|---|---|---|---|
| Sex | Focal | Diffuse | Total |
| Male | 1/10 (10) | 5/10 (50) | 5/10 (50) |
| Female | 8/19 (42) | 13/19 (68) | 18/19 (95) |
| Fisher's exact test (male vs. female) | P = 0.42 | P = 0.43 | P = 0.01 |
Male and female BALB/c mice were infected with 2 × 105 PFU/eye of HSV-IL-2, and the optic nerves were dissected at 14 days after infection, fixed, sectioned, and stained with LFB. Data for female mice are combined from four separate experiments. Data are presented as the number of mice showing optic nerve demyelination/total mice tested (%).