Table 2.

Associations between Diameter Change in Response to Acetylcholine (%ΔD) and Low Wall Shear Stress using Linear Regression with Generalized Estimating Equations to Account for Within-Subject Correlations.

Variables	Univariate Models		Multivariable Model
	Estimated difference in %ΔD (95%CI)	p-value	Estimated difference in %ΔD (95%CI)	p-value
Age, years	−0.0003 (−0.003 – 0.002)	0.81	0.01 (−0.01 – 0.01)	0.38
Female	−0.069 ( −0.138 – 0.0004)	0.05	−0.07 (−0.13 – −0.01)	0.03
African American	−0.002(−0.064 – 0.059)	0.95	0.03 (−0.05 – 0.07)	0.74
Hypertension	−0.013 (−0.084 – 0.058)	0.71	−0.01(−0.09 – −0.06)	0.70
Diabetes Mellitus	−0.145 (−0.178 – 0.112)	<0.001	−0.22 (−0.22 – −0.09)	< 0.001
Active Smoker	−0.041 (−0.110 – 0.028)	0.24	−0.05 (−0.13 – −0.037)	0.28
Hyperlipidemia	−0.006 (−0.074 – 0.062)	0.87	−0.015 (−0.08 – −0.05)	0.64
Low Wall Shear Stress	−0.110 (−0.142 – 0.077)	< 0.001	−0.11 (−0.18 – −0.047)	< 0.001