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. 2018 Sep 6;38(11):2718–2730. doi: 10.1161/ATVBAHA.118.311209

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© 2018 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 3. — Leading edge analysis. Leading edge analysis identified major biological states upregulated in human macrophages from recently symptomatic carotid atherosclerotic plaques. These include inflammation, particularly cytokine response and interferon signaling; lipid metabolism; cell proliferation and apoptosis; antigen presentation; as well as cellular energetics. Each column represents a significantly enriched pathway (P<0.05; false discovery rate, <0.25), whereas each row represents a leading edge gene. GO indicates gene ontology.