Figure 1. A direct comparison of the embryonic expression pattern and intensity of the Cre reporter R26R:lacZ when crossed with different EC-specific Cre alleles on the C57/Bl6 background.

Embryonic age was established from date of plug in mother, all embryos were fixed, stained and sectioned using identical conditions across each age group as previously described¹⁰⁸. For tamoxifen administration, 100μl tamoxifen (10mg/ml in a 10:1 solution of peanut oil and 100% ethanol) was administered orally via gavage on two consecutive days as indicated, and embryos taken 48 hours after last dose. When two embryos for the same allele are shown, they are littermates. E=embryonic day, da=dorsal aorta, cv=cardinal vein, end=endocardial lining of heart