Table 3. Susceptible host gene polymorphisms in normal cases and the combined cohort of EV71 cases.
| Gene | Genotype/ | Normal cases (N = 98) | EV71 cases (N = 599) | Logistic regression analysis | ||||
|---|---|---|---|---|---|---|---|---|
| (SNP) | Allele | No. | % | No. | % | ORa | (95% CI)a | P valuea |
| SCARB2 | ||||||||
| rs6824953 | CC | 15 | 15.3 | 64 | 10.7 | Ref. | ||
| Intron | GC | 53 | 54.1 | 255 | 42.7 | 1.32 | (0.55, 3.16) | 0.54 |
| GG | 30 | 30.6 | 278 | 46.6 | 2.49 | (1.00, 6.21) | 0.05 | |
| C | 83 | 42.4 | 383 | 32.1 | Ref. | |||
| G | 113 | 57.7 | 811 | 67.9 | 1.60 | (1.07, 2.39) | 0.02 | |
| rs11097262 | TT | 13 | 13.3 | 57 | 9.6 | Ref. | ||
| Intron | CT | 51 | 52.0 | 256 | 42.9 | 1.79 | (0.68, 4.72) | 0.24 |
| CC | 34 | 34.7 | 284 | 47.6 | 3.04 | (1.13, 8.23) | 0.03 | |
| T | 77 | 39.3 | 370 | 31.0 | Ref. | |||
| C | 119 | 60.7 | 824 | 69.0 | 1.64 | (1.09, 2.47) | 0.02 | |
EV71, enterovirus 71; SCARB2, scavenger receptor class B member 2.
aThe ORs, 95% CIs, and P values were calculated by multivariate logistic regression with adjustment for age and gender.