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. 2018 Oct 24;14(10):e1006469. doi: 10.1371/journal.pcbi.1006469

Fig 4. Quantitation of histological characteristics of spheroids and comparison with outputs of the SABM.

Fig 4

The overall diameter (circles), diameter of the necrotic region (triangle), and thickness of viable rim (plotted here as twice the viable rim thickness, rectangles) of HCT116 spheroids were quantitated using H&E stained histological sections illustrated in Fig 3. Values are means ± SD (n = 4 spheroids, 5 on day 7). The lines are the corresponding outputs of SABM simulations using oxygen and glucose parameters fitted to monolayer and MCL experimental data (See Table 1).