Fig 1. Survival rate, body weight, and clinical score of ICR suckling mice infected with ZIKV by i.p. and i.c. injection.

Six-day-old ICR suckling mice received 10² to 10⁵ PFU ZIKV by i.c. (n = 5) or i.p. (n = 5) injection. (A–D) Survival rate, (E–H) clinical score, and (I–L) body weight recorded every day. Mice were sacrificed at 8 dpi. Disease severity was scored as follows: 0: healthy, 1: body weight loss and ruffled fur, 2: lethargy and unsteady gait, 3: kinetic tremors and severe ataxia, 4: paralysis, and 5: death.