Table 2.
PVE corrected | PVE uncorrected | |||||||
18F-Flut + | 18F-Flut– | Ratio | p | 18F-Flut + | 18F-Flut – | Ratio | p | |
A. SUV | ||||||||
WMH | 767.72 (193.92) | 633.21 (173.71) | 1.21 | 0.015a | 700.66 (170.81) | 575.13 (159.05) | 1.22 | 0.019a |
NAWM | 1028.62 (190.89) | 932.33 (240.24) | 1.10 | 0.112a | 978.49 (187.30) | 848.64 (224.09) | 1.15 | 0.035a |
WM | 1020.95 (195.67) | 913.18 (242.43) | 1.12 | 0.081a | 918.69 (187.59) | 749.75 (211.26) | 1.23 | 0.007a |
Cerebellum cortex | 429.59 (109.05) | 389.58 (142.53) | 1.10 | 0.143a | 429.13 (112.64) | 391.34 (147.88) | 1.10 | 0.169a |
Cerebellum WM | 921.76 (192.45) | 830.06 (248.26) | 1.11 | 0.121a | 920.51 (192.29) | 828.68 (248.16) | 1.11 | 0.120a |
Brainstem | 1025.93 (233.15) | 933.80 (305.42) | 1.10 | 0.157a | 1031.65 (232.99) | 938.33 (307.75) | 1.10 | 0.157a |
B. SUVr | ||||||||
Precun + post.cing. | 2.17 (0.54) | 0.89 (0.14) | 2.44 | <0.001b | 1.97 (0.31) | 1.23 (0.14) | 1.60 | <0.001b |
Anterior cingulate | 1.94 (0.50) | 0.78 (0.12) | 2.49 | <0.001b | 1.88 (0.28) | 1.20 (0.13) | 1.57 | <0.001b |
Prefrontal | 2.15 (0.53) | 0.92 (0.11) | 2.34 | <0.001b | 1.78 (0.28) | 1.13 (0.10) | 1.58 | <0.001b |
Inferior parietal | 2.15 (0.50) | 1.01 (0.11) | 2.13 | <0.001b | 1.80 (0.27) | 1.21 (0.11) | 1.49 | <0.001b |
Lateral temporal | 1.92 (0.43) | 0.91 (0.12) | 2.11 | <0.001b | 1.70 (0.23) | 1.17 (0.10) | 1.45 | <0.001b |
Hippocampus | 1.07 (0.07) | 1.05 (0.06) | 1.02 | 0.274b | 1.25 (0.10) | 1.24 (0.12) | 1.01 | 0.526b |
Parahippocampal | 1.33 (0.26) | 0.76 (0.09) | 1.75 | <0.001b | 1.35 (0.12) | 1.07 (0.10) | 1.26 | <0.001b |
Entorhinal | 1.14 (0.24) | 0.90 (0.09) | 1.27 | 0.002b | 1.19 (0.14) | 1.04 (0.12) | 1.14 | 0.003b |
Values are given in standardized uptake value (SUV) in A and in standardized uptake value ratio (SUVr) in B. aCalculated using Independent-samples T test. bCalculated using Mann-Whitney U test. Ratio and p-values indicate 18F-Flut + versus 18F-Flut –. Statistically significant group differences are shown in bold. PVE, partial volume effects; WMH, white matter hyperintensities; NAWM, normal-appearing white matter; WM, white matter.