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. 2018 Mar 27;62(4):1595–1607. doi: 10.3233/JAD-170582

Table 2.

Regional 18F-Flutemetamol uptake in 18F-Flut(+) versus 18F-Flut(–)

PVE corrected PVE uncorrected
18F-Flut + 18F-Flut– Ratio p 18F-Flut + 18F-Flut – Ratio p
A. SUV
WMH 767.72 (193.92) 633.21 (173.71) 1.21 0.015a 700.66 (170.81) 575.13 (159.05) 1.22 0.019a
NAWM 1028.62 (190.89) 932.33 (240.24) 1.10 0.112a 978.49 (187.30) 848.64 (224.09) 1.15 0.035a
WM 1020.95 (195.67) 913.18 (242.43) 1.12 0.081a 918.69 (187.59) 749.75 (211.26) 1.23 0.007a
Cerebellum cortex 429.59 (109.05) 389.58 (142.53) 1.10 0.143a 429.13 (112.64) 391.34 (147.88) 1.10 0.169a
Cerebellum WM 921.76 (192.45) 830.06 (248.26) 1.11 0.121a 920.51 (192.29) 828.68 (248.16) 1.11 0.120a
Brainstem 1025.93 (233.15) 933.80 (305.42) 1.10 0.157a 1031.65 (232.99) 938.33 (307.75) 1.10 0.157a
B. SUVr
Precun + post.cing. 2.17 (0.54) 0.89 (0.14) 2.44 <0.001b 1.97 (0.31) 1.23 (0.14) 1.60 <0.001b
Anterior cingulate 1.94 (0.50) 0.78 (0.12) 2.49 <0.001b 1.88 (0.28) 1.20 (0.13) 1.57 <0.001b
Prefrontal 2.15 (0.53) 0.92 (0.11) 2.34 <0.001b 1.78 (0.28) 1.13 (0.10) 1.58 <0.001b
Inferior parietal 2.15 (0.50) 1.01 (0.11) 2.13 <0.001b 1.80 (0.27) 1.21 (0.11) 1.49 <0.001b
Lateral temporal 1.92 (0.43) 0.91 (0.12) 2.11 <0.001b 1.70 (0.23) 1.17 (0.10) 1.45 <0.001b
Hippocampus 1.07 (0.07) 1.05 (0.06) 1.02 0.274b 1.25 (0.10) 1.24 (0.12) 1.01 0.526b
Parahippocampal 1.33 (0.26) 0.76 (0.09) 1.75 <0.001b 1.35 (0.12) 1.07 (0.10) 1.26 <0.001b
Entorhinal 1.14 (0.24) 0.90 (0.09) 1.27 0.002b 1.19 (0.14) 1.04 (0.12) 1.14 0.003b

Values are given in standardized uptake value (SUV) in A and in standardized uptake value ratio (SUVr) in B. aCalculated using Independent-samples T test. bCalculated using Mann-Whitney U test. Ratio and p-values indicate 18F-Flut + versus 18F-Flut –. Statistically significant group differences are shown in bold. PVE, partial volume effects; WMH, white matter hyperintensities; NAWM, normal-appearing white matter; WM, white matter.