Table 1.

Working groups and number of data points collected for this study

				Strain measured
Class of readout	Readout	Data	Age range (weeks)	Bl10/mdx	Bl10/wt	D2/mdx	D2/wt	Contributors
Natural History	Lean and fat mass	394	6–12			*	*	Pfizer
	Body weight	2800	4–65	*	*	*	*	Aartsma-Rus, De Luca, Duan, Jax, Nagaraju, Pfizer, Sarepta, Spencer
	Tissue weights (excluding heart)	2135	4–65	*	*	*	*	Aartsma-Rus, De Luca, Duan, Nagaraju, Pfizer
	Tibia length	18	23–30			*	*	Duan
Functional	Wheel (voluntary and exhaustion)	318	8–58	*	*	*	*	De Luca, Nagaraju
	Open field (all assessments)1	376	8–65		*	*	*	Jax, Nagaraju, Spencer
	Grip strength (incl. normalized &hang test)	4142	4–65	*	*	*	*	Aartsma-Rus, De Luca, Jax, Nagaraju, Sarepta, Spencer
	Rotarod	612	6–65	*	*	*	*	Jax, Nagaraju, Sarepta
	Hindlimb sonography2	72	28	*	*	*	*	De Luca
	Force (all muscles, all conditions)	1816	8–65	*	*	*	*	De Luca, Duan, Jax, Nagaraju, Pfizer
Cardiac	Functional assessments3	761	16–58			*	*	De Luca, Duan, Nagaraju
	Size/weight assessments	288	4–65			*	*	Aartsma-Rus, Duan, Nagaraju
Histology	All assessments4	1240	8–78			*	*	Aartsma-Rus, Duan, Jax, Nagaraju, Yokata
Respiratory	All assessments	1174	4–34			*	*	Aartsma-Rus, Spencer
Therapeutics	Gene expression in response to exon skipping	71	13	*		*		Aartsma-Rus
Biomarkers	CK	574	8–64	*	*	*	*	Aartsma-Rus, De Luca, Jax, Nagaraju
	LDH	76	9–64	*	*	*	*	De Luca
	Serum biomarkers5	37	13–36			*	*	Duan, Nagaraju
	Dystrophin level	12	13	*		*		Aartsma-Rus
	Gene expression6	939	10–34	*	*	*	*	Aartsma-Rus, Jax

¹ Includes open field distance run, Digiscan measurements, and # of rearings.

² Includes volume and % vascularization.

³ Shortening fraction, ejection fraction, stroke volume, and cardiac output also measured in Bl10 mice.

⁴ Fiber area, fibrosis area, and % calcification also measured in Bl10 mice.

⁵ Includes WBCs, macrophages, and neutrophils.

⁶ Gene expression values from 12 genes in two different tissues (gastrocnemius and diaphragm).