Table 3.

Individual and mean P8 concentrations (ng/mL) in rat plasma and CSF following a single intravenous dose (11.0 mg/kg)

Matrix	Time (min)	Rat I.D.			Mean	SD
		Rat 1	Rat 2	Rat 3
Plasma	0	BQL	BQL	BQL	0.00	0.00
	5	102,000	45,300	43,600	63,600	33,200
	15	9,880	12,600	8,460	10,300	2,100
	25	4,250	5,650	3,230	4,380	1,210
	35	2,160	2,710	1,770	2,210	472
	50	878	1,190	713	927	242
	70	392	313	199	301	97.0
	90	97.3	105	166	123	37.6
	110	93.1	36.4	39.8	56.4	31.8
	130	42.0	18.3	20.7	27.0	13.0
	165	18.9	NSR	9.72	14.3	6.49
CSF	0	BQL	BQL	BQL	0.00	0.00
	10	61.1c	50.1c	85.7c	65.6	18.2
	30	42.5	48.2c	39.3	43.3	4.51
	60	22.8	17.8	16.9	19.2	3.18
	100	10.7	8.69	4.08	7.82	3.39
	150	4.88	4.30	3.57	4.25	0.656
	180	4.11	NSR	1.06	2.59	2.16

NSR-No Sample Received.