Table 3.

SPECT VAChT studies in PD and parkinsonian dementia

Reference	VAChT ligand	Population	Main findings and clinical correlates
(D. Kuhl et al., 1996).	[123I]-IBVM	PD/D	More severe and extensive VAChT binding losses in PDD compared to PD. In PD without dementia, binding was reduced only in parietal (−19%) and occipital cortex (−21%). Non-significant increases were seen in the anterior cingulum (+5%) and striatum (+8%) in the PD patients.
(Mazere et al., 2017).	[123I]-IBVM	DLB	Prominent VAChT cortical and subcortical (thalamus, basal ganglia) losses were observed in the DLB patients compared to normal control subjects.