Table 6.

Topographic and covariance changes of cholinergic receptor changes in PD and parkinsonian dementia: Implication for large-scale brain networks.

Reference	Radioligand	Population	Main findings and clinical correlates
(Colloby et al., 2016).	[123I]-QNB mAChR	PDD	Reduced mAChR binding in basal forebrain, temporal, striatal, insula, and anterior cingulate regions together with concomitant preserved or increased binding in frontal and parieto-occipital areas.
(Isaias et al., 2014).	[123I]-5IA α4β2* nAChR	PD	Reduced regional nAChR binding (caudate nucleus, orbitofrontal cortex, and the middle temporal gyrus) but with higher binding in the putamen, insular cortex and the supplemental motor area.