Table 2.
Area under the ROC curve (AUC) for the diagnosis of UTI normalized and non-normalized uNGAL, clinical opinion, and nitrites, for all patients and all patients without augmented bladders
| Predictor | AUC | Cut-off value | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | Positive likelihood ratio | Negative likelihood ratic | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Patients with augmented bladders included | ||||||||||
| Diagnosis of UTI versus no UTI | ||||||||||
| UTI definition does not include nitrites (n with UTI = 24) | uNGAL (pg/g crt) | 0.89 (0.80–0.98) | 817 | 83 | 91 | 58 | 97 | 9.2 | 0.2 | |
| uNGAL (ng/mL) | 0.88 (0.80–0.97) | 229 | 83 | 86 | 47 | 97 | 5.9 | 0.2 | ||
| UTI definition does include nitrites (n with UTI = 11) | uNGAL (pg/g crt) | 0.82 (0.65–1.0) | 817 | 82 | 85 | 26 | 81 | 5.5 | 0.2 | |
| uNGAL (ng/mL) | 0.84 (0.67–0.99) | 228 | 91 | 81 | 23 | 99 | 4.8 | 0.1 | ||
| Diagnosis of UTI versus UTC | ||||||||||
| UTI definition does not include nitrites (n with UTI = 24) | uNGAL (pg/g crt) | 0.84 (0.73–0.95) | 817 | 80 | 83 | 67 | 91 | 4.7 | 0.2 | |
| uNGAL (ng/mL) | 0.83 (0.63–0.94) | 229 | 80 | 83 | 67 | 91 | 4.7 | 0.2 | ||
| UTI definition does include nitrites (nwith UTI =11) | uNGAL (pg/g crt) | 0.76 (0.57–0.94) | 817 | 82 | 70 | 29 | 96 | 2.7 | 0.3 | |
| uNGAL (ng/mL) | 0.79 (0.62–0.97) | 229 | 91 | 72 | 33 | 98 | 3.3 | 0.1 | ||
| Patients with augmented bladders excluded | ||||||||||
| Diagnosis of UTI versus no UTI | ||||||||||
| UTI definition does not include nitrites (n with UTI = 21) | uNGAL (pg/g crt) | 0.90 (0.80–1.0) | 856 | 86 | 92 | 62 | 98 | 10.8 | 0.2 | |
| uNGAL (ng/mL) | 0.89 (0.80–0.99) | 229 | 86 | 89 | 54 | 98 | 7.8 | 0.2 | ||
| UTI definition does include nitrites (nwith UTI =10) | uNGAL (pg/g crt) | 0.82 (0.63–1.0) | 856 | 80 | 86 | 27 | 99 | 5.7 | 0.2 | |
| uNGAL (ng/mL) | 0.84 (0.65–1.0) | 229 | 90 | 84 | 26 | 99 | 5.6 | 0.1 | ||
| Diagnosis of UTI versus UTC | ||||||||||
| UTI definition does not include nitrites (n with UTI = 21) | uNGAL (pg/g crt) | 0.85 (0.74–0.97) | 856 | 81 | 85 | 49 | 96 | 5.4 | 0.2 | |
| uNGAL (ng/mL) | 0.85 (0.74–0.96) | 229 | 82 | 85 | 49 | 96 | 5.5 | 0.2 | ||
| UTI definition does include nitrites (nwith UTI = 10) | uNGAL (pg/g crt) | 0.75 (0.55–0.95) | 1035 | 70 | 81 | 39 | 94 | 3.7 | 0.4 | |
| uNGAL (ng/mL) | 0.78 (0.59–0.97) | 229 | 90 | 72 | 36 | 98 | 3.2 | 0.1 | ||
A UC area under the curve, ROC receiver operator characteristic, uNGAL urine neutrophil gelatinase-associated lipocalin, UTC urinary tract colonization, UTI urinary tract infection