Skip to main content
. Author manuscript; available in PMC: 2018 Nov 5.
Published in final edited form as: Clin Sci (Lond). 2018 Jul 31;132(14):1615–1627. doi: 10.1042/CS20180398

Figure 1.

Figure 1.

Expression of apoptosis signal-regulating kinase 1 (ASK1) in human lung. IHC analysis of ASK1 in human lung tissue (20x) obtained from healthy (non-COPD, A) and diseased lung donors (COPD, B), isotype control is shown (C). ImageJ analysis of ASK1 expression in the airway wall is shown as % ASK1 expression (D) and ASM layer (E). Western blot analysis showing expression of ASK1 in human airway smooth muscle cells obtained from non-COPD and COPD donors (F). Results are expressed as mean ± SEM. 4–6 patient samples were used in each treatment group. Data were analyzed by unpaired t-test (*p<0.05, **p <0.01, **p <0.001). Arrowheads represents location of airway smooth muscle bundles in the airway. Scale bar, 50 μm.