REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti-LC3B	Novus Biologicals	Cat# NB100-2220; RRID: AB_10003146
Mouse monoclonal anti-LC3B (clone 5F10)	Nanotools	Cat# 0231-100; RRID: AB_2722733
Rabbit polyclonal anti-SQSTM1/P62	MBL	Cat# PM045; RRID: AB_1279301
Rabbit polyclonal anti-VDAC	Millipore	Cat# AB10527; RRID: AB_10806766
Rat monoclomal anti-LAMP1 (clone 1D4B)	Abcam	Cat# ab25245; RRID: AB_449893
anti-HLADR (clone L243)	Biolegend	Cat# 30762728
anti-CD86 (clone IT2.2)	Biolegend	Cat# 30540506
anti-CD80 (clone 2D10)	Biolegend	Cat# 305219
anti-CD14 (clone HCD14)	Biolegend	Cat# 325605
anti-pS6K PECy7 (clone CUPK43K)	eBioscience	Cat# 25900741
anti-p4EBP1 PE (clone V3NTY24)	invitrogen	Cat# 12-9107-41
Chemicals, Peptides, and Recombinant Proteins
Universal Type I interferon, human	PBL	Cat# 11200-1
Recombinant human IL-4	Peprotech	Cat# 200-04
Recombinant human GMCSF	Peprotech	Cat# 300-03
Resomer RG 503 H, Poly(D,L-lactide-co-glycolide) acid terminated, lactide:glycolide 50:50, Mw 24,000-38,000	SIGMA	Cat#:719870
Critical Commercial Assays
Cathepsin D Activity Assay Kit (fluorometric)	Abcam	Cat# ab65302
ATP assay kit	Abcam	Cat# ab83355
Amaxa Human Dendritic Cell Electroporation kit	Lonza	Cat# VPA-1004
Mitochondrial Isolation Kit for cultured cells	Thermo Scientific	Cat# 89874
VeriKine Human Interferon Alpha Multi-Subtype Serum ELISA Kit	PBL	Cat# 41110-1
HumanTNFα Ready-Set-Go ELISA	eBioscience	Cat# 887346
Human IL6 Ready-Set-Go ELISA	eBioscience	Cat# 887066
Human CXCL10(IP-10) ELISA	eBioscience	Cat# BMS284INST
FITC AnnexinV apoptosis Detection kit	BD Bioscience	Cat# 556547
Deposited Data
RNA-seq data, SRA Bioproject PRJNA392602	NCBI’s Short Read Archive	https://www.ncbi.nlm.nih.gov/bioproject/PRJNA392602/
Oligonucleotides
Stealth siRNA (Set of 3), TMEM173/STING Human, HSS139156,HSS139157,HSS139158	Life Technologies	Cat# 1299003
Stealth siRNAs (Set of 3), TLR9 Human, HSS147622, HSS147623, HSS147624	Life Technologies	Cat# 1299003
Stealth siRNA Negative Control Kit	Life Technologies	Cat# 12935-100
Primers for IFNα, CXCL10, SQSTM1/P62, LC3, PINK1, Parkin, ATG5, huβ2Μ, mtMinArc (STAR Methods)	this paper	N/A
STING (TMEM173) primers and probe (FAM): Hs00736958_m1 assay	Life Technologies	Cat# 4331182
GAPDH primers and probe (HEX) Hs03929097_g1	Life Technologies	Cat# 4448489
TLR9 primers and probe: Hs00152973_m1 (FAM)	Life Technologies	Cat# 4331182
Software and Algorithms
GraphPad Prism	N/A	https://www.graphpad.com
Fiji		https://fiji.sc/
Macro for % colocalization for Fiji software	Daniel J. Shiwarski	N/A
Other
CD14 MicroBeads, human	Miltenyi	Cat# 130-050-201
Monocyte Isolation Kit II (negative selection), human	Miltenyi	Cat# 130-091-153
CD4+ CD25+ Regulatory T Cell Isolation Kit, human	Miltenyi	Cat# 130-091-301
Lysosensor Green DND-189	Life Technologies	Cat# L7535
LysoTracker Red DND-99	Life Technologies	Cat# L7528
Mitotracker Red	Life Technologies	Cat# M7512
CellTrace CFSE Cell Proliferation Kit	Life Technologies	Cat# C34554
MitoSOX Red Mitochondrial Superoxide Indicator	Life Technologies	Cat# M36008
MitoTEMPO	SIGMA	Cat# SML0737
Rapamycin	SIGMA	Cat# 553210 EMD Millipore
Plaquenil (hydroxychloroquine)	Sanofi Aventis	ATC code 8P01BA02
DOTAP liposomal transfection reagent	Roche	REF: 11202375001