Figure 5.

The Histone Methylation Patterns of Kmt2b^−/− MEFs Prefigure Gene Repression in Untransdifferentiated cKO Cells

(A) MEF H3K4me3 coverage (in reads per kilobase million [RPKM]) in Kmt2b^−/−, control, and double-mutant MEFs 2 and 7 days after the last 4-OHT administration around the TSS of DEGs in Kmt2b^−/− and control transdifferentiating cells.

(B) MEF H3K4me3 RPKM around the TSS of genes downregulated in both PSA-NCAM fractions (left) and in Kmt2b^−/− PSA-NCAM⁺ cells only (right).

(C) H3K27me3 RPKM around the TSS of genes downregulated in Kmt2b^−/− PSA-NCAM⁻ cells, in MEFs, and at 5 days of transdifferentiation.