Table 3. Brain regions with significant metabolic decrease in MDD patients compared with HC subjects.
| Region* | Side | Size (voxels) | Coordinatesa | Zmax | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| Insula | L | 59 | −36 | −9 | 3 | 3.74 |
| Claustrum | L | −27 | −3 | 3 | 3.69 | |
| Putamen | R | 55 | 33 | 0 | 0 | 4.21 |
| IFGoperc | R | 29 | 51 | 12 | 15 | 4.41 |
| SMAR | R | 23 | 66 | −27 | 30 | 3.67 |
*, uncorrected P<0.001, extend threshold >20. a, Montreal Neurological Institute (MNI) standard space. MDD, major depressive disorder; L, left; R, right; IFGoperc, inferior frontal gyrus, opercular part; SMAR, supramarginal gyrus.