Table 3:

Medical comorbidities and medications notably associated with severe persistent post-surgical pain after cataract surgery (defined as a Dry Eye Questionnaire-5 score of 12 or greater)

	SPPP (n=22)	Wo SPPP (n=97)	Odds ratio	95% CI	P-value
Demographic
Gender, n (%) female, female/male	16 (73%)	50 (52%)	2.51	0.91–6.95	0.07
Neurologic			yes/no
Non-ocular chronic pain (headache, migraine, low back pain, fibromyalgia), n (%)	4 (18%)	5 (5%)	4.09	1.00–16.7	0.06
Rheumatologic
Sjögrens, n (%)	2 (9%)	0 (0%)	NC	NC	0.03
Any autoimmune condition (RA/SLE/Sjögrens/PMR/MS), n (%)	4 (18%)	3 (3%)	6.96	1.44–33.8	0.02
Ocular
Artificial tears on record, n (%)	6 (27%)	3 (3%)	11.8	2.67–51.8	0.001
Lifitegrast/cyclosporine, n (%)	4 (18%)	4 (4%)	5.17	1.18–22.6	0.04
Psychiatric
Anti-depressant, n (%)	8 (36%)	19 (20%)	2.35	0.86–6.40	0.10
Anxiolytic, n (%)	5 (23%)	10 (10%)	2.56	0.78–8.43	0.15
Anti-insomnia, n (%)	4 (18%)	3 (3%)	6.96	1.44–33.8	0.02

SPPP: Severe Persistent Post-surgical Pain, WoSPPP: Without Severe Persistent Post-surgical Pain, NC: Not Calculable, PMR: Polymyalgia Rheumatica, RA: Rheumatoid Arthritis, SLE: Systemic Lupus Erythematosus, MS: Multiple Sclerosis