Figure 3:

Line graphs of exploratory efficacy biomarkers demonstrating absolute change in Relative Fluorescence Units (RFU) from Baseline to Day 14 in VBP15–002. Shown are 4 dose levels. Baseline values were compared with Day 14 values using a two-tailed paired t-test. Asterisks (*) indicate significant increases from baseline (pre-dose) to following 2 weeks of treatment (post-dose) for a given dose level (p<0.05). Abbreviations: BL= baseline; RFU = Relative Fluorescence Units; MDC = macrophage-derived chemokine; IL22 BP = interleukin-22 binding protein; IGFBP2 = insulin-like growth factor binding protein 2; ITGA1 ITGB1 = integrin a1b1; MMP 12 = matrix metalloproteinase 12