Table 4.

Results of 6MWT multiple linear regression analysis (n = 119)

Model with all covariates
	Estimate	Std. error	t value	Pr(>|t|)	Partial correlation
(Intercept)	282.08	112.65	2.50	0.0138	0.00
rsFC: MLR–SFG/ACC (BnS 12), Fisher z	174.52	52.87	3.30	0.0013	0.29
rsFC: MLR–cerebellum (BnS 253), Fisher z	126.90	48.13	2.64	0.0097	0.25
rsFC: CLR–M1F (BnS 67), Fisher z	−70.32	57.95	−1.21	0.2277	−0.12
No. fMRI motion outlier volumes, 0–260	2.85	1.48	1.93	0.0566	0.20
Mean fMRI framewise displacement, mm	−116.91	110.84	−1.06	0.2940	−0.12
Age, years	0.04	0.44	0.09	0.9276	0.01
Male sex	−2.82	14.43	−0.20	0.8457	−0.02
Height, inch	1.93	1.30	1.48	0.1410	0.14
Body mass index, kg/m2	0.85	1.56	0.55	0.5870	0.06
Resting heart rate, bpm	−0.78	0.91	−0.86	0.3921	−0.10
Resting systolic blood pressure, mmHg	−0.73	0.79	−0.93	0.3568	−0.11
Dyspnea rating, 0–4	−18.82	15.57	−1.21	0.2294	−0.10
Depression score (BDI), 0–63	−0.38	1.73	−0.22	0.8243	−0.02
Visuoconstructional ability (WASI‐BD), 20–80	0.22	0.86	0.25	0.8035	0.02
Residual standard error: 66.04 on 104 degrees of freedom. Multiple R‐squared: 0.3261, adjusted R‐squared: 0.2354. F‐statistic: 3.595 on 14 and 104 DF, p value: 7.65e‐05.
Model with rsFC variables only
	Estimate	Std. error	t value	Pr(>|t|)	Partial correlation
(Intercept)	285.71	13.21	21.63	0.0000	0.00
rsFC: MLR–SFG/ACC (BnS 12), Fisher z	185.21	50.39	3.68	0.0004	0.30
rsFC: MLR–cerebellum (BnS 253), Fisher z	164.01	42.92	3.82	0.0002	0.33
rsFC: CLR–M1F (BnS 67), Fisher z	−64.10	52.87	−1.21	0.2279	−0.11
Residual standard error: 66.26 on 115 degrees of freedom. Multiple R‐squared: 0.2497, adjusted R‐squared: 0.2302. F‐statistic: 12.76 on 3 and 115 DF, p value: 2.949e‐07.

6MWT = 6‐minute walk test; rsFC = resting‐state functional connectivity; MLR = midbrain locomotor region; CLR = cerebellar locomotor region; SFG = superior frontal gyrus, ACC = anterior cingulate cortex; M1F = primary motor cortex foot/leg area; BDI = Beck depression inventory II; WASI‐BD = Wechsler abbreviated scale of intelligence ‐ block design.