Table 5.
ROI location specificity analysis (n = 119). Mean seed rsFC association with walking capacity across ROIs for the a priori, alternative, and control seeds
| Seed | Reference | Seed coordinates | Mean |T| | Max |T| | Significant rsFC–6MWT association ROIs (p FDR < .05) |
|---|---|---|---|---|---|
| MLR | Peterson 2014* | ±6, −26, −15 | 1.23 | 3.67 | 12 |
| Peterson 2014† | −5/+8, −27, −14 | 1.19 | 3.56 | 253 | |
| Fox 2014 | ±6, −27, −15 | 1.16 | 3.96 | 12, 253 | |
| Fling 2013 | ±7, −32, −22 | 0.94 | 2.77 | None | |
| Cremers 2012 | ±4, −26, −22 | 0.85m | 2.88 | None | |
| Karachi 2010 | ±3, −22, −13 | 0.79m | 2.52 | None | |
| Snijders 2011 | 0, −28, −20 | 0.77m | 2.32 | None | |
| Snijders 2016 | ±6, −33, −20 | 0.71m | 2.49 | None | |
| Fling 2014 | −5/+8, −32, −22 | 0.70m | 2.17 | None | |
| CLR | Jaeger 2014 | ±8, −42/−44, −26 | 1.15 | 3.46 | (67) |
| Peterson 2014† | 0/+2, −49, −28 | 0.91c | 2.65 | None | |
| Jahn 2008* | ±6, −48, −14 | 0.89c | 3.21 | None | |
| Peterson 2014* | 0, −46, −33 | 0.87c | 2.08 | None | |
| Cremers 2012 | ±2, −58, −16 | 0.77c | 3.06 | None | |
| Fling 2014 | −6/+9, −55, −18 | 0.73c | 3.10 | None | |
| Fasano 2017 | −20/+16, −44, −26 | 0.68c | 2.35 | None | |
| M1F | Buckner 2011 | ±6, −26, 76 | 1.01 | 3.45 | None |
| SMA | Fox 2014 | 0, 1, 63 | 0.69mc | 2.23 | None |
| PMd | Fox 2014 | ±31, −5, 68 | 1.03 | 2.77 | None |
rsFC = resting‐state functional connectivity; ROI = region of interest; MLR = midbrain locomotor region; CLR = cerebellar locomotor region; M1F = primary motor cortex foot area; SMA = supplemental motor area; PMd = dorsal premotor cortex. 6MWT = 6‐min walk test; FDR = false discovery rate corrected.
Seeds were spheres centered on given coordinates with 3 mm radius for MLR and 6 mm radius for CLR, M1F, SMA, and PMd. Italicized seeds were a priori primary seeds. For each seed, the absolute values of the rsFC–6MWT association T values (adjusted for age, sex, height, body mass index, and summary head motion measures) were obtained for all 81 ROIs to calculate mean and max |T|. Alternative seeds are ordered by this mean |T| value. In the far‐right column, the ROI number in parentheses denotes a negative rsFC–6MWT association.
*Brett transformed from Talairach to MNI152 space using tal2mni (http://imaging.mrc-cbu.cam.ac.uk/imaging/MniTalairach) [Brett et al., 2002].
†Lancaster transformed from Talairach to FSL MNI152 space using tal2icbm_fsl (http://www.brainmap.org/icbm2tal) [Lancaster et al., 2007].