Table 5.
Complications and Outcomes by Peak Level of Hemolysis
| Peak Hemolysis |
|||||
|---|---|---|---|---|---|
| Variable a,b | None (N = 4) |
Mild (N = 67) |
Moderate (N = 51) |
Severe (N = 94) |
P-value |
| Thrombocytopenia | 0 (0.0%) | 21 (25.6%) | 21 (25.6%) | 40 (48.8%) | 0.067c |
| New documented infection | 1 (1.7%) | 17 (29.3%) | 14 (24.1%) | 26 (44.8%) | 0.746c |
| Bleeding event | 3 (1.7%) | 47 (26.9%) | 42 (24.0%) | 83 (47.4%) | 0.005c |
| Thrombotic event | 0 (0.0%) | 19 (17.9%) | 28 (26.4%) | 59 (55.7%) | <.001c |
| Neurologic organ failure | 1 (1.4%) | 15 (20.5%) | 17 (23.3%) | 40 (54.8%) | 0.008c |
| Renal organ failure | 1 (1.1%) | 13 (14.0%) | 22 (23.7%) | 57 (61.3%) | <.001c |
| Hepatic organ failure | 1 (1.2%) | 20 (23.3%) | 21 (24.4%) | 44 (51.2%) | 0.026c |
| Duration of ECMO (days) | 4.3 [2.8, 5.8] | 3.7 [2.5, 6.2] | 5.4 [2.9, 9.0] | 8.6 [4.3, 12.3] | <.001d |
| Length of ICU stay (days) | 33.3 [16.3, 107.0] | 29.6 [14.1, 48.2] | 29.9 [17.1, 48.9] | 29.4 [15.7, 50.8] | 0.692d |
| Length of hospital stay (days) | 40.7 [16.3, 127.8] | 46.1 [18.7, 83.4] | 41.6 [19.9, 77.9] | 36.4 [16.1, 61.1] | 0.210d |
| In-hospital mortality | 1 (1.0%) | 24 (23.3%) | 26 (25.2%) | 52 (50.5%) | 0.010c |
a
Variables reported had no missing values.
b
A limitation in this table is that the timing of some outcomes relative to hemolysis is not considered.
c
Cochran-Armitage trend test.
d
Jonckheere-Terpstra test.