Table 6.
Multivariable Cox Model of Renal Failure
| Renal Failure |
||
|---|---|---|
| Variablea | Hazard ratio (95% CI) |
P-value |
| Plasma free hemoglobin (for each 0.1 g/L increase) | 1.04 (1.02, 1.06) | <.001 |
| Location of ECMO care | 0.014 | |
| PICU | 1.28 (0.60, 2.75) | |
| NICU | 0.36 (0.17, 0.76) | |
| CICU | Reference | |
| Hemoglobin (g/dL) (10 g/L) | 1.20 (1.03, 1.40) | 0.019 |
| Lactate (mmol/L) | 1.06 (1.00, 1.11) | 0.035 |
This analysis includes only the 184 subjects without renal failure at baseline; of those, 59 developed renal failure. In addition to the variables used in the model for plasma free hemoglobin, this also uses daily bleeding and thrombosis as potential predictors and forces plasma free hemoglobin in as a predictor. Importantly, need for in-line hemofiltration and continuous renal replacement therapy is not considered as a potential predictor.
a
Rates of missingness for all predictors considered for modeling are included in Supplemental Digital Content 2. The outcome, renal failure, was never missing.