Figure 3 -.

Effects of corticotropin releasing factor (CRF) fragment 6–33, a CRF binding protein antagonist, administered into the bed nucleus of the stria terminalis of rats exposed to intermittent social defeat stress or non-stressed controls. a. Number of entries into the interaction zone; b. Time spent in the interaction zone; c. Number of entries into the object zone; d. Time spent in object zone. The interaction zone contained an unfamiliar female placed inside a small acrylic cage and the object zone contained an empty small acrylic cage. Data are mean ± SEM; * stressed vs. non-stressed rats treated with saline; # saline infusion vs. CRF_6–33 0.25 µg/0.2 µl in stressed rats; p < 0.05, n = 13–14 rats per group. e. Total distance travelled measured in meters. The animals were tested during the habituation period (5 min) in the central chamber of the three-chamber apparatus. The central chamber measures 0.5 × 0.5 m. Data are mean ± SEM; n = 12 rats per group