Table 1.

Newly Identified Loci Associated with CRP

Varianta	Positionb	Coded Allele	Frequency of Coded Allele	βc	Standard Error	p Value	Closest Gened	1KG Lead Variante
Loci Found in the HapMap GWAS
rs469772	chr1: 91,530,305	T	0.19	−0.031	0.005	5.54 × 10−12	ZNF644	rs469882
rs12995480	chr2: 629,881	T	0.17	−0.031	0.005	1.24 × 10−10	TMEM18	rs62105327
rs4246598	chr2: 88,438,050	A	0.46	0.022	0.004	5.11 × 10−10	FABP1	–
rs9284725	chr2: 102,744,854	C	0.24	0.027	0.004	7.34 × 10−11	IL1R1	rs1115282
rs1441169	chr2: 214,033,530	G	0.53	−0.025	0.004	2.27 × 10−11	IKZF2	–
rs2352975	chr3: 49,891,885	C	0.30	0.025	0.004	6.43 × 10−10	TRAIP	rs10049413
rs17658229	chr5: 172,191,052	C	0.05	0.056	0.010	5.50 × 10−9	DUSP1	rs34471628
rs9271608	chr6: 32,591,588	G	0.22	0.042	0.005	2.33 × 10−17	HLA-DQA1	rs2647062
rs12202641	chr6: 116,314,634	T	0.39	−0.023	0.004	3.00 × 10−10	FRK	–
rs1490384	chr6: 126,851,160	T	0.51	−0.025	0.004	2.65 × 10−12	C6orf173	rs1490384
rs9385532	chr6: 130,371,227	T	0.33	−0.026	0.004	1.90 × 10−11	L3MBTL3	–
rs1880241	chr7: 22,759,469	G	0.48	−0.028	0.004	8.41 × 10−14	IL6	rs13241897
rs2710804	chr7: 36,084,529	C	0.37	0.021	0.004	1.30 × 10−8	KIAA1706	–
rs2064009	chr8: 117,007,850	C	0.42	−0.027	0.004	2.28 × 10−14	TRPS1	rs6987444
rs2891677	chr8: 126,344,208	C	0.46	−0.020	0.004	1.59 × 10−8	NSMCE2	rs10956251
rs643434	chr9: 136,142,355	A	0.37	0.023	0.004	1.02 × 10−9	ABO	9:136146061
rs1051338	chr10: 91,007,360	G	0.31	0.024	0.004	2.27 × 10−9	LIPA	–
rs10832027	chr11: 13,357,183	G	0.33	−0.026	0.004	4.43 × 10−12	ARNTL	rs10832027
rs10838687	chr11: 47,312,892	G	0.22	−0.031	0.004	9.12 × 10−13	MADD	rs7125468
rs1582763	chr11: 60,021,948	A	0.37	−0.022	0.004	2.37 × 10−9	MS4A4A	rs1582763
rs7121935	chr11: 72,496,148	A	0.38	−0.022	0.004	5.28 × 10−9	STARD10	–
rs11108056	chr11: 95,855,385	G	0.42	−0.028	0.004	5.42 × 10−14	METAP2	rs12813389
rs2239222	chr14: 73,011,885	G	0.36	0.035	0.004	9.87 × 10−20	RGS6	rs2239222
rs4774590	chr15: 51,745,277	A	0.35	−0.022	0.004	2.71 × 10−8	DMXL2	rs1189402
rs1558902	chr16: 53,803,574	A	0.41	0.034	0.004	5.20 × 10−20	FTO	rs55872725
rs178810	chr17: 16,097,430	T	0.56	0.020	0.004	2.95 × 10−8	NCOR1	–
rs10512597	chr17: 72,699,833	T	0.18	−0.037	0.005	4.44 × 10−14	CD300LF, RAB37	rs2384955
rs4092465	chr18: 55,080,437	A	0.35	−0.027	0.004	3.11 × 10−10	ONECUT2	–
rs12960928	chr18: 57,897,803	C	0.27	0.024	0.004	1.91 × 10−9	MC4R	–
rs2315008	chr20: 62,343,956	T	0.31	−0.023	0.004	5.36 × 10−10	ZGPAT	–
rs2836878	chr21: 40,465,534	G	0.27	0.043	0.004	7.71 × 10−26	DSCR2	rs4817984
rs6001193	chr22: 39,074,737	G	0.35	−0.028	0.004	6.53 × 10−14	TOMM22	rs4821816
Additional Loci Found in the 1KG GWAS
rs75460349	chr1: 27,180,088	A	0.97	0.086	0.014	4.50 × 10−10	ZDHHC18	–
rs1514895	chr3: 170,705,693	A	0.71	−0.027	0.004	2.70 × 10−9	EIF5A2	–
rs112635299	chr14: 94,838,142	T	0.02	−0.107	0.017	2.10 × 10−10	SERPINA1, SERPINA2	–
rs1189402	chr15: 53,728,154	A	0.62	0.025	0.004	3.90 × 10−9	ONECUT1	–
Additional Loci Found in the BMI-Adjusted 1KG GWAS
3:47431869	chr3: 47,431,869	D	0.59	0.024	0.004	1.10 × 10−8	PTPN23	–
rs687339	chr3: 135,932,359	T	0.78	−0.030	0.005	2.80 × 10−10	MSL2	–
rs7795281	chr7: 74,122,854	A	0.76	0.028	0.005	3.10 × 10−8	GTF2I	–
rs1736060	chr8: 11,664,738	T	0.60	0.029	0.004	2.60 × 10−13	FDFT1	–
17:58001690	chr17: 58,001,690	D	0.44	−0.026	0.004	9.50 × 10−10	RPS6KB1	–
rs9611441	chr22: 41,339,367	C	0.49	−0.022	0.004	1.40 × 10−8	XPNPEP3	–

^aHapMap variants are presented, except for the 1KG additional findings.

^bPositions are according to UCSC Genome Browser build hg19.

^cβ coefficients represent a 1-unit change in the natural-log-transformed CRP (mg/L) per copy increment in allele A1.

^dThe closest gene represents either the gene in which the variant is located or the closest gene.

^eFor HapMap loci, the lead variant from the 1KG GWAS is presented when the loci were also found in the 1KG GWAS.