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. 2018 Oct 30;9:2570. doi: 10.3389/fmicb.2018.02570

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Copyright © 2018 Li, Wang, Cao, Deng, Jiang, Wu and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IRF3 and IRF7 play an important role in enhancing the humoral immunity of ATRA and NAFL. 5 μl SIV were immunized i.d. alone or with adjuvant ATRA or combined with NAFL (2 hits, high) in wild-type C57BL/6 mice, IRF3^-/- and IRF7^-/- knockout mice, and vaccine-specific antibody titer for (A) IgG, (B) IgG1 and (C) IgG2c were determined 2 weeks post-immunization. N = 4. Data are presented as mean ± s.e.m. ^∗P < 0.05; ^∗∗P < 0.01 or ^∗∗∗P < 0.001, respectively.