Table 2B.
Clinical-demographic model on BNT: naming nouns controlled for normalized volume of the 12 left language areas and their homologs plus demographic (gender, age and education) and clinical features (years post-onset, dementia severity, language severity).
| Variable | Fraction of std change in BNT, per 1 unit* change in variable (SE) | t-stat | P-value | R2 | Added R2 |
|---|---|---|---|---|---|
| Stepwise regression of each ROIs, demographic and clinical features | |||||
| Language severity | −0.90 (0.18) | −5.16 | <0.001 | 34% | 34% |
| L MTG | 0.55 (0.14) | −3.89 | <0.001 | 47% | +13% |
| Stepwise regression of each ROIs, demographic and clinical features, including variant | |||||
| Language severity | −0.99 (0.16) | −6.14 | <0.001 | 34% | 34% |
| Sv variant | −2.34 (0.35) | −6.76 | <0.001 | 52% | +18% |
| Lv variant | −0.97 (0.36) | −2.66 | 0.012 | 55% | +3% |
| Edu | −0.15 (0.05) | −2.70 | 0.011 | 59% | +4% |
*Units are in 1 std of variables except for the indicators of variants Sv, Lv. Abbreviations: Language severity, severity score at the language subtest of the FTLD–CDR; BNT, Boston Naming Test, left inferior frontal gyrus pars orbitalis; L MTG, left middle temporal gyrus; Sv, semantic variant PPA; Lv, logopenic variant PPA; Edu, years of education. The Added R-squared from the regression model refers to the additional variance explained by including the given variable.