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. 2018 Nov 5;9:4624. doi: 10.1038/s41467-018-06853-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — H19 expression is decreased in pituitary adenomas. a H19 expression is decreased in human prolactinomas compared with that in normal pituitary glands from healthy subjects. The SurePrint G3 Human GE 8 × 60 K Microarray was used to profile lncRNA expression in human normal pituitary glands and prolactinomas (GSE119063). Heatmap showing the differential expression of lncRNAs in normal pituitary (n = 4) and prolactinomas (n = 5), including the decreased level of H19 in prolactinomas. Right box plot panel shows that H19 expression is decreased approximately 1.51-fold in prolactinomas. b H19 expression is decreased in human gonadotropic adenoma (GEO dataset GSE26966). Statistical significance was determined by one-way ANOVA followed by Tukey’s multiple comparison test. ***p < 0.001. c Decreased expression of H19 in prolactinomas, GH tumours and nonfunctioning pituitary tumours compared with that in three normal pituitary tissues. Statistical analysis was determined by paired Student’s t-test. ***p < 0.001. d H19 is decreased by 3.24-fold in 37 pituitary tumours compared with that in three normal pituitary tissues. Total RNA was extracted from 37 different subtypes of human pituitary tumours, and qRT-PCR was performed to assess H19 abundance in these pituitary adenomas (PRL = 9, NFPA = 20, GH = 6, ACTH = 2); mRNA levels were normalized to β-actin mRNA. ***p < 0.001, two-tailed Student’s t-test was used for statistical analysis. e H19 expression level is negatively corrected with tumour volume in patients (p = 0.015, by Pearson’s, n = 37). Error bars are the mean ± SEM values