Table 2.

Relative risk of PCa for polygenic risk score (PRS) groups

Risk category percentilea	No. of individuals		Risk estimates for PRS groups
	Controls	Cases	OR (95% CI)b	p-value
≤1%	530	339	0.52 (0.45–0.59)	2.11 × 10−20
1%–10%	4771	3636	0.62 (0.59–0.65)	6.26 × 10−90
10%–25%	7936	7359	0.75 (0.72–0.78)	3.62 × 10−54
25%–75%	26,464	32,743	1.00 (Ref)
75%–90%	7940	13,431	1.37 (1.32–1.41)	6.55 × 10−77
90%–99%	4766	11,451	1.93 (1.86–2.01)	4.13 × 10−249
>99%	528	2576	3.99 (3.62–4.40)	5.64 × 10−172

Note: PRS were calculated for variants from the final stepwise model with allele dosage from OncoArray and iCOGS weighted by the per-allele conditionally adjusted odds ratios from the meta-analysis

^aRisk category groups were based on the percentile distribution of risk alleles in overall controls

^bEstimated effect of each PRS group relative to the interquartile range (25–75%) in OncoArray and iCOGS datasets separately, and then meta-analyzed across the two studies; odds ratios were adjusted for country and 7(OncoArray)/8(iCOGS) principal components