Table 1.

A list of the change of DNA methylation status of fibrosis related genes of db/db mice.

Gene	DNA Methylation
Growth Factor
Tgfb1	↓
TgfrII	↓
Ctgf	↓
Ppdgf	↓
Igf-1	↓
Igf-2	n.s.
Igf biding protein 1	n.s.
Igf R	n.s.
Smad 2	n.s.
Smad 3	n.s.
Glut 1	↑
Glut 2	↑
Col IV	n.s.
Fibronectin	n.s.
α-sma	n.s.
Pai-1	↓
Mmp-2	↓
Mmp-9	↓
Vcam-1	n.s.
Icam-1	n.s.
Reactive oxygen species
Nox-1	↑
Nox-4	n.s.
Txnip	↑
Rage	n.s.
Inflammation
p65	↓
Il-6	n.s.
Mcp-1	n.s.
Usf1	↓
Srebp1	↓
At1a	↓
At1b	↓