Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 5;8:16324. doi: 10.1038/s41598-018-34427-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

TCDD exposure since the conception impairs thyroid function. (a) fT4 serum levels were determined by ELISA in C57BL/6 males (black bar) and females (white bar) exposed at 0,001 μg/kg/day TCDD (TCDD) or not (CTRL), from E0.5 to PND30. (b) Body weight analysis of CTRL and TCDD-treated mice (male on the left and female on the right). (c) Hematoxylin and Eosin thyroid staining of CTRL- and TCDD-males (top panels) and females (bottom panels). (d–g) RT-qPCR analysis of Tsh transcript in pituitary and Pax8, Nkx2-1 and Nis transcripts in thyroid of CTRL- and TCDD-males (black bar) and TCDD-females (white bar). Data are reported as means ± SD of Gapdh normalized-mRNA levels; n = 5 mice for each group and sex. *p-value < 0.05; **p-value < 0.01; ***p-value < 0.001 treated vs control mice.