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. 2018 Nov 5;8:16324. doi: 10.1038/s41598-018-34427-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Haploinsufficiency of Pax8 or Nkx2-1 exacerbates the effects of TCDD treatment. Expression of thyroid specific transcripts in unexposed or 0,1 μg/kg/day TCDD exposed mice (from E15.5 to PND60) of each genotype. Thyroid Pax8, Nkx2-1 and Nis transcripts were assayed by RT-qPCR in C57BL/6 wild type (wt), Pax8^+/− and Nkx2-1^+/− (at left of the dashed lines) and in TCDD-wt, -Pax8^+/− and -Nkx2-1^+/− (at right of the dashed lines), males (a,b and c) and females (d,e and f). Data are reported as means ± SD of Gapdh normalized-mRNA levels; n = 4 mice for each group. *p-value < 0.05; **p-value < 0.01 for statistical analysis of TCDD-exposed vs untreated mice having the same genotype; ^#p-value < 0.05; ^##p-value < 0.01 TCDD-exposed vs TCDD-wt mice; ^†p-value < 0.05 unexposed mice of different genotype vs wt mice.