Table 3.
Proteins measured in plasma of patients enrolled in CALGB 80303 and 80203.
| Soluble Angiogenic Factors | Matrix-Derived Angiogenic Factors | Markers of Vascular Activation and Inflammation | ||
|---|---|---|---|---|
| ANG-2 | PEDF | Osteopontin | CRP | PAI-1 Active |
| bFGF | PlGF | TGFβ1 | Gro-α | PAI-1 Total |
| HGF | VEGF-A | TGFβ2 | ICAM-1 | P-selectin |
| IGF-1 | VEGF-C | sTGFβRIII | IL-6 | SDF1 |
| IGFBP1 | VEGF-D | TSP2 | IL-8 | VCAM-1 |
| IGFBP3 | sVEGFR1 | MCP-1 | ||
| PDGF-AA | sVEGFR2 | |||
| PDGF-BB | ||||
ANG-2 = angiopoietin-2; bFGF = basic fibroblast growth factor; HGF = hepatocyte growth factor; IGF-1 = insulin-like growth factor-1; IGFBP = insulin-like growth factor-binding protein; PDGF = platelet-derived growth factor; PEDF = pigment epithelium-derived factor; PlGF = placental growth factor; VEGF = vascular endothelial growth factor; sVEGFR = soluble vascular endothelial growth factor receptor; TGFβ = transforming growth factor beta; sTGFβRIII = soluble transforming growth factor beta receptor type III; TSP = thrombospondin; CRP = c-reactive protein; PAI-1 = plasminogen activator inhibitor-1; Gro-α = growth regulated oncogene-alpha; ICAM-1 = intercellular adhesion molecule 1; IL = interleukin; MCP-1 = macrophage chemoattractant protein-1; SDF1 = stromal cell-derived factor-1; VCAM-1 = vascular cell adhesion molecule 1.