FIGURE 4.

Olig2 is an oligodendrocyte universal marker. Olig2 (red) colocalizes (A, cortex and corpus callosum) with cell cycle KI-67 marker (green) as seen in the merge picture (orange), and also (B, cortex) with the chondroitin sulfate proteoglycan NG2 (green), evidence for its presence in the proliferative and migratory precursor population. (C, olfactory bulb) Olig2 is also present in the pre-myelinating and myelinating phase, since it colocalizes with CNPAse (gray), and (D, corpus callosum; E, fornix) with well-known adult oligodendrocytes markers such as MBP (green) and CC1, characteristic of the end of maturation. Scale bar (valid for all panels): 10 μm.