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. 2018 Nov 5;8:16334. doi: 10.1038/s41598-018-34642-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) A stacked bar chart of significantly enriched pathways derived from the differential proteins in the CSF data. Gray solid bars represent proteins that were not detected as differentially abundant. Horizontal and diagonal dashed bars represent proteins that are up- and down regulated, respectively. Left axis is the percentage of proteins detected in that pathway (top number) as unchanged or different. Right axis displays the significance of the enrichment. (B) Interaction network analysis of differentially abundant proteins. The size of the circle is proportional to the significance (i.e., p-value) while the shade is indicative of the fold change. Clusters of proteins were isolated and subjected to GO analysis to determine biological function.