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. 2018 Oct 30;6:143. doi: 10.3389/fcell.2018.00143

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Copyright © 2018 Nakagawa, Chen and Rathinam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deregulated molecular signatures in IKK2^CA HSCs. Gene ontology (GO) analysis of microarray data: top 10 major GO terms of molecular function among upregulated genes (>1.5 fold) (A) and downregulated genes (<0.67 fold) (B) in IKK2^CA LT-HSCs. Gene set enrichment analysis (GSEA) of microarray data from IKK2^CA versus control LT-HSCs with the following gene sets: genes enriched in normal, steady-state BM HSCs from WT mice compared to multi potent progenitors (MPPs), leukemic stem cells (LSCs), and mobilized HSCs (C). Genes enriched in HSCs, but not in MPPs (D). Genes enriched in human HSCs of cord blood (E). Quiescent stem cell genes, which are commonly upregulated in HSCs, muscle stem cells and hair follicle stem cells (F). Genes enriched in proliferative HSCs, which are commonly upregulated in fetal liver HSCs (vs. adult HSCs) and 2, 3, and 6 days after 5FU injection (vs. 0, 1, 10, 30 days after 5FU injection) (G).