Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 30;6:143. doi: 10.3389/fcell.2018.00143

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Nakagawa, Chen and Rathinam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Altered transcription factor networks in IKK2^CA HSCs. (A) Gene ontology analysis of microarray data: the 10 most significantly enriched GO terms (function) in upregulated genes (>1.5 fold) in IKK2^CA LT-HSCs. P-values were calculated by DAVID 6.7 software. (B) Differentially expressed transcription factors (TFs) in IKK2^CA LT-HSCs. Highlighted TFs have been shown to regulate HSC self-renewal, quiescence, and differentiation. (C) Real time PCR data for Relb, Junb, and Gfi1 in IKK2^CA or Control LT-HSCs. Expression levels of target genes were normalized to HPRT levels. Data are representative of two independent experiments. All data represent mean ± SEM. Two-tailed Student’s t-tests were used to assess statistical significance (^∗P < 0.05 and ^∗∗P < 0.005).