Table 3.
Genetic associations with NEs in the total sample, aMCI, and naMCI groups from the ACE dataset.
| MCI group | 3A MCI total sample |
3B aMCI |
3C naMCI |
||||||
|---|---|---|---|---|---|---|---|---|---|
| NE | NBACE-L | NBACE-DR | NBACE-RE | NBACE-L | NBACE-DR | NBACE-RE | NBACE-L | NBACE-DR | NBACE-RE |
| N | 1243 | 1243 | 1243 | 809 | 809 | 809 | 434 | 434 | 434 |
| β | –1.35 | –0.76 | –0.58 | –0.80 | –0.36 | –0.36 | –0.12 | –0.23 | 0.17 |
| L95/U95 | –1.95/-0.76 | –1.00/-0.51 | –0.88/-0.27 | –1.37/-0.23 | –0.53/-0.18 | –0.71/-0.02 | –1.07/0.82 | –0.56/0.09 | –0.16/0.49 |
| p-Value | 2.91 × 10-6∗ | 4.10 × 10-10∗ | 9.67 × 10-5∗ | 0.004 | 2.96 × 10-5∗ | 0.029 | 0.792 | 0.138 | 0.300 |
aMCI, amnestic mild cognitive impairment; naMCI, non-amnestic mild cognitive impairment; NE, neurocognitive endophenotype; NBACE, neuropsychological battery of Fundació ACE; NBACE-L, learning on memory assessed according to WMS-III within NBACE; NBACE-DR, delayed recall on memory assessed according to WMS-III within NBACE; NBACE-RE, recognition on memory assessed according to WMS-III within NBACE; β, unstandardized regression coefficient; L95/U95, lower/upper 95% confidence intervals. ∗Statistically significant after Bonferroni’s correction (p ≤ 1.69 10-E-5).