Table 4.
Genetic associations with NE in the total sample, aMCI, and naMCI groups from AgeCoDe and DCN datasets.
| AgeCoDe | 4A MCI Total sample |
4B aMCI |
4C naMCI |
||||||
|---|---|---|---|---|---|---|---|---|---|
| NE | CERAD-IR | CERAD-DR | CERAD-RE | CERAD-IR | CERAD-DR | CERAD-RE | CERAD-IR | CERAD-DR | CERAD-RE |
| N | 499 | 495 | 499 | 191 | 187 | 192 | 308 | 308 | 307 |
| β | –1.14 | –0.41 | –1.77 | –1.10 | –0.32 | –2.32 | –0.52 | –0.14 | –0.08 |
| L95/U95 | –1.88/-0.41 | –0.83/0.004 | 3.55/0.003 | –2.08/-0.11 | –0.90/0.25 | –4.96/0.31 | –1.55/0.50 | –0.68/0.41 | –2.47/2.31 |
| p-Value | 0.002 | 0.052 | 0.051 | 0.030 | 0.027 | 0.085 | 0.317 | 0.623 | 0.945 |
| DCN |
4D MCI total sample |
4E aMCI |
4F naMCI |
||||||
| NE | LM-IR | LM-DR | CERAD-RE | LM-IR | LM-DR | CERAD-RE | LM-IR | LM-DR | CERAD-RE |
| N | 556 | 556 | 550 | 274 | 274 | 272 | 282 | 282 | 278 |
| β | –2.32 | –2.70 | –1.69 | –2.29 | –2.78 | –1.73 | –1.51 | –1.41 | 0.26 |
| L95/U95 | –3.27/-1.38 | –3.73/0.52 | –3.08/-0.30 | –3.42/-1.15 | –4.04/-1.51 | –3.84/-0.11 | –2.99/-0.03 | –2.92/0.09 | –0.86/1.39 |
| p-Value | 1.85 × 10-6∗ | 3.00 × 10-7∗ | 0.017 | 9.9 × 10-5 | 2.18 × 10-5 | 0.110 | 0.046 | 0.077 | 0.643 |
NE, neurocognitive endophenotype; aMCI, amnestic mild cognitive impairment; naMCI, non-amnestic mild cognitive impairment; CERAD, the consortium to establish a registry for Alzheimer’s disease; CERAD-IR, CERAD-immediate recall; CERAD-DR, CERAD-delayed recall; CERAD-RE, CERAD-recognition; LM-IR, logical memory immediate recall of the story from the Wechsler memory scale; LM-DR, logical memory delayed recall of the story assessed according to the Wechsler memory scale; β, unstandardized regression coefficient; L95/U95, lower/upper 95% confidence intervals. ∗Statistically significant after Bonferroni’s correction (p ≤ 0.05).