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. 2018 Oct 30;10:33. doi: 10.3389/fnsyn.2018.00033

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Copyright © 2018 Cheng, Song and Augustine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of synapsins in augmentation and potentiation. (A) Time course of changes in normalized mEPSC frequency produced by electrical activity (50 Hz, 2 s stimulation) in TWT (black) and TKO (red) neurons. Points indicate mean values of mEPSC frequency (n = 7), normalized to baseline values measured prior to the stimulus train, and error bars indicate ± SEM. (B) Peak amount of augmentation of mEPSC frequency, calculated from exponential fits to the data in panel (A), in TWT (black) and TKO (red) neurons. (C) Amount of potentiation of mEPSC frequency in TWT (black) and TKO (red) neurons. Values in panles (B,C) indicate means and error bars indicate ± SEM, while asterisks indicate significant differences (p < 0.05) between TWO and TKO.