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. 2018 Oct 30;10:33. doi: 10.3389/fnsyn.2018.00033

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Copyright © 2018 Cheng, Song and Augustine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of elevating presynaptic cAMP levels on mEPSC frequency in TWT neurons. (A) Time course of changes in normalized mEPSC frequency (red symbols) produced by application of forskolin (10 μM) during time indicated by red bar. Electrical stimulation (50 Hz, 2 s) was applied at time = 0. (B) Time course of changes in mEPSC frequency (green symbols) produced by application of IBMX (0.5 mM) during time indicated by green bar. Electrical stimulation (50 Hz, 2 s) was applied at time = 0. (C) Mean values of mEPSC frequency measured in control conditions (black), as well as in the presence of forskolin (FSK; red) and IBMX (green). Values indicate means, error bars indicate ±SEM, and asterisks indicate significant differences compared to values measured in control conditions.