Figure 2.

Hypothetical GWAS Locus with Two Signals that Affect Two Genes

(A) Plot of association for two signals within 100 kb at a single GWAS locus. The first signal is shown by red circles, and the second is shown by blue triangles. The intensity of color corresponds to the strength of LD between the lead variant and other variants in the signal.

(B) Hypothetical regulatory marks overlapping the positions of candidate variants. Arrows point to variants that overlap predicted regulatory regions: four for signal 1 and four for signal 2. Signal 1 variants could target gene 1, and signal 2 variants could target gene 2 because variants are located in each respective promoter.