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. 2018 Oct 30;9:2513. doi: 10.3389/fimmu.2018.02513

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Copyright © 2018 Ren, Li, Zhang, Zhao, Fang, Li, Chen, Zhang, Wang, Pan and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DSC suppressed caerulein-induced inflammation in vitro and in vivo. Chemical structure of DSC (A), the quantitative analyzes of IL-1β, TNF-α and MCP-1 in supernatants of 266-6 cells were shown (B–D). Pancreatic edema (E), serum amylase (F), serum lipase levels (G) and pancreatic histology (H) in BALB/c mice were determined. Control (CON): saline treatment. Caerulein (CAE): caerulein treatment. DSC, DSC-prophylactic treatment. Danshensu: danshensu-prophylactic treatment. Data shown are means ± SEM. *P < 0.05, ^**P < 0.01, ^***P < 0.001, and ^****P < 0.0001.