Table 5.
Sinus augmentation with primary outcome measure related to new bone formation (mean ± SD, 95% CI, and P value).
| Studies | Intervention group | N | Measurement methods | Follow-up (month) | Control group (C) | Test group (T) | Power of statistic |
|---|---|---|---|---|---|---|---|
| Schmitt CM et al., 2013 (RCT) | T: Biphasic calcium phosphate (BCP) with 60% HA | 14 | Histomorphometric (newly formed bone) | 5 | C1: 24.90 ± 5.67% C2: 35.41 ± 2.78% C3: 41.74 ± 2.10% |
T: 30.28 ± 2.16% | P = 0.000 between T & C3 |
| C: Inorganic bovine bone (ABB) | 15 | ||||||
| C2: Bone allograft (MCBA) | 12 | ||||||
| C3: Autologous bone (AB) | 12 | ||||||
| Ghanaati S et al., 2013 (RCT) | T: Synthetic HA (NanoBone) | 4 | Histomorphometric (newly formed bone) | 6 | C: 25.73 ± 7.94% | T: 21.85 ± 5.96% | P > 0.05 (Pval < 0.05) |
| C: Deproteinized bovine bone (Bio-Oss) | 4 | ||||||
| Lezzi G et al., 2012 (CCT) | T1: Phycogene HA (Algipore) | 6 | Histomorphometric (newly formed bone) | 6 | C1: 31.8 ± 2.9% C2: 32.9 ± 0.5% |
T1: 33.2 ± 1.2% T2: 30.5 ± 3.4% T3: 28.1 ± 3.9% |
P < 0.05 (Pval < 0.05) |
| T2: Macroporous biphasic CaPO4 (MBCP) | 6 | ||||||
| T3: Calcium carbonate (Biocoral) | 6 | ||||||
| C1: Collagenized porcine cortical/cancellous bone (Apatos) | 6 | ||||||
| C2: Inorganic bovine bone (ABB) | 6 | ||||||
| Kurkcu M et al., 2012 (CCT) | T: β-Tri calcium phosphate or β-TCP (Kasios) | 13 | Histomorphometric (newly formed bone) | 6.5 | 30.13 ± 3.45% | 21.09 ± 2.86% | P = 0.001 (Pval < 0.05) |
| C: Inorganic bovine derivate HA (Bone Plus-XS) | 13 | ||||||
| Lorenz J. et al., 2014 (CCT) | T: Synthetic HA (NanoBone) | 7 | Histomorphometric (nexwly formed bone) | 7 | 22.66 ± 7.97% | 19.02 ± 7.28% | P > 0.05 (Pval < 0.05) |
| C: Deproteinized bovine bone (Bio-Oss) | 7 | ||||||
| Lindrgen C et al., 2012 (RCT) | T: Biphasic calcium phosphate (BCP) | 5 | Histomorphometric (newly formed bone) | 8 | 31.7 ± 18.0% | 28.6 ± 14.3% | P = 0.67 (Pval < 0.05) |
| C: Deproteinized bovine bone (DBB) | 5 | ||||||
| Boeck-Neto RJ et al., 2001 (CCT) | T: Autogenous + HA | 5 | Histomorphometric (newly formed bone) | 10 | 50.46 ± 16.29% | 46.79 ± 8.56% | NA |
| C: Autogenous + DFDBA | 5 | ||||||
| Mangano C et al., 2007 (CCT) | T: Porous synthetic HA | 20 | Histomorphometric (newly formed bone) | 12 | 36.2 ± 1.4% | 34.7 ± 3.1% | P = 0.031 (Pval < 0.05) |
| C: Bovine derivate HA | 20 | ||||||
| Artzi Z et al., 2001 (RCT) | T: Synthetic nonceramic resorbable HA (NC-HA) | 14 | Histomorphometric (bone area fraction at 10 sites) | 12 | 42.1 ± 10.0% | 32.2 ± 8.15% | NA |
| C: Natural deproteinized bovine HA (BHA) | 14 | ||||||
| Baena RR et al., 2013 (RCT) | T: Polyacid-HA (PLGA/HA) | 4 | Radiographic by CT (bone density) | 6 | 946 ± 161.9 | 286 ± 134.4 | P = 0.002 (Pval < .05) |
| C: Deproteinized bovine bone | 4 | ||||||
| Tosta M et al., 2013 (RCT) | T: Biphasic calcium phosphate (with 60% HA and 40% β-TCP) + Membrane collagen C: Particulate autogenous + Membrane collagen |
15 15 |
Histomorphometric (area fraction of mineralized bone) | 9 | Area 1: 41.03 ± 4.62% Area 2: 38.63 ± 7.52% |
Area 1: 33.70 ± 8.08% Area 2: 26.68 ± 3.92% |
P1 = 0.008 P2 < 0.001 (Pval < 0.05) |
| Lindgren C et al., 2010 (CCT) | T: β-TCP + HA | 11 | Histological analysis EDS (Ca/P Ratio) |
8 | 1.72 ± 0.07 | 1.63 ± 0.02 | NA |
| C: Deproteinized Bovine Bone | 11 | ||||||
| Karabuda C et al., 2001 (CCT) | T: Porous HA (PHA) | 3 | Histomorphometric (newly formed bone) | 6 | C1: 70–75% C2: 50% |
20–35% | NA |
| C1: Demineralized freeze-dried bone powder (DFBP) | 1 | ||||||
| C2: Deproteinized bovine bone granule (DBBG) | 5 | ||||||
| Lorenzetti M et al., 1998 (CCT) | T: Autogenous from chin + PHA (Interpore 200) | 3 | Histomorphometric (newly formed bone) | 8&12 | C1: 53% C2: 69.3% C3: 62.6% |
T: 44.3% | NA |
| C1: Autogenous from iliac | 4 | ||||||
| C2: Autogenous from chin | 3 | ||||||
| C3: Particulate autogenous | 3 | ||||||
| Kuhl S et al., 2012 (CCT) | T: Blood + PAB + β-TCP | 10 | Radiographic by CT (bone density) | NA | #C: 0.5 | #T1: 0.08 #T2: 0.00031 |
P = 0.341 (Pval < 0.05) |
| T: Blood + PAB + β-TCP/HA | 10 | ||||||
| C: Blood + PAB | 10 | ||||||
| Kuhl S et al., 2013 (CCT) | T1: Blood + Autogenous Bone (PAB) + β-TCP | 10 | Radiographic by μ-CT (Volume fraction bone) | 5 | 18.5% | T1: 17.1% T2: 21.7% |
P = 0.578 |
| T2: Blood + PAB + β-TCP/HA | 10 | ||||||
| C: Blood + PAB | 10 |