Table 2.
List of some genes, which have been found to play a significant role in the development of oral carcinoma.
| Gene | Locus | Function | Reference |
|---|---|---|---|
| CCND1 | 11q13 | Cell cycle regulation | [72, 76, 77, 78, 79, 86] |
| CTTN | 11q13 | F-actin binding protein | [72, 74, 75] |
| FADD | 11q13 | Regulation of apoptosis | [83] |
| ORAOV1 | 11q13 | Regulation of apoptosis and angiogenesis | [84, 85] |
| TP53 | 17p13 | Regulation of cell cycle and apoptosis | [87] |
| FAK/PTK2 | 8q23–24 | Cellular adhesion and spreading | [74] |
| PIK3CA | 3q26 | Regulation of receptor- mediated extracellular stimuli | [86] |
| SOX2 | 3q26 | Transcription factor | [86] |
| EGFR | 7p12 | Receptor for epidermal growth factor protein ligands | [90, 91, 92] |