Table 4.
Basic characteristics of significant ROHs associated with lung cancer
| ROH | Chr | Position | Freq | Cases: controls | Chi2 | P | Pad | Located gene | iHS max | Fay and Wu's H max | Fst max | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Start | End | ||||||||||||
| ROH_14857 | 2 | 39025631 | 39047154 | 0.048 | 198:230 | 14.47 | 1.43×10-4 | 0.044 | DHX57 | 1.284 | -22.097 | 0.360 | |
| ROH_14715 | 2 | 39084756 | 39135927 | 0.049 | 200:232 | 14.49 | 1.41×10-4 | 0.044 | DHX57, MORN2 | 2.623 | -36.364 | 0.433 | |
| ROH_14344 | 2 | 39198965 | 39226271 | 0.049 | 206:238 | 14.57 | 1.35×10-4 | 0.044 | ARHGEF33, SOS1 | 1.798 | -39.925 | 0.290 | |
| ROH_14342 | 2 | 39247288 | 39293530 | 0.050 | 207:237 | 13.85 | 2.00×10-4 | 0.044 | SOS1 | 2.010 | -56.961 | 0.271 | |
Freq: frequency; Chr: chromosome; Chromosomal positions are shown according to NCBI Build 37 (hg19); P: P-value for testing the differences of homozygosity status between cases and controls with two-sided chi-square test; Pad: P-value adjusting with the Benjamini and Hochberg (BH) procedure; Located gene: ROHs located gene; iHS max: the maximal absolute values for iHS; Fay and Wu's H max: the maximal absolute values for Fay and Wu's H; and Fst max: the maximal absolute values for Fst; iHS max, Fay and Wu's H max and Fst max were derived for Asian population from Haplotter (http://haplotter.uchicago.edu/) using Phase II HapMap Project data.