Table 3.
Univariate and multivariate Cox regression analyses of the autophagy-related signature and clinical characteristics predictive of overall survival and disease-free survival.
| Variable | Overall survival | Disease-free survival | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR |
 -value |
HR |
 -value |
HR |
 -value |
HR |
 -value |
|
| Eight-gene signature | 0.414 | <0.001 | 0.463 | <0.001 | 0.488 | <0.001 | 0.599 | 0.007 |
| (low-risk vs high-risk) | ||||||||
| Age (old age vs young age) | 1.019 | 0.001 | 1.016 | 0.033 | 1.012 | 0.058 | ||
| Tumor grade (G3-G4 vs G1-G2) | 1.180 | 0.056 | 1.219 | 0.051 | ||||
| FIGO stage | 1.658 | 0.003 | 1.837 | 0.040 | 1.432 | 0.084 | ||
| (stage III-IV vs stage I-II) | ||||||||
| Residual tumor size | 0.436 | <0.001 | 0.578 | 0.037 | 0.478 | 0.002 | 0.487 | 0.016 |
| (no macroscopic vs visible macroscopic) | ||||||||
| BRCA1/2 mutation stage | 2.021 | 0.001 | 1.874 | 0.004 | 1.752 | 0.020 | 1.602 | 0.065 |
| (no mutation vs mutation) | ||||||||
| Lymphatic invasion | 1.422 | 0.114 | 1.491 | 0.148 | ||||
| (invasion vs no invasion) | ||||||||
| Venous invasion (no invasion vs invasion) | 0.973 | 0.917 | 0.714 | 0.311 | ||||
HR: hazard ratio